Neuro Pharmacology Section 11- Carbidopa/Levodopa, COMT Inhibitors (Entacapone, Tolcapone)

TOPICS: Parkinson disease, levodopa, L-dopa analog, cross blood brain barrier, DOPA decarboxylase, carbidopa, increase bioavailability, peripheral DOPA decarboxylase inhibitor, decrease peripheral adverse effects of L-DOPA, reduce postural hypotension, nausea/vomiting, hot flashes, risk of arrhythmias, entacapone, tolcapone, inhibit COMT, hallucinations, confusion, anxiety, insomnia, agitation, delusion, on-off phenomenon, reducing dose, atypical antipsychotics

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